Publications
Featured
Publications
1 / Tethered Cord Syndrome in KBG Syndrome
Hills S., Pugacheva A., Weltin P., Maughan A., Morton S., Feldman H., Klinge P., Agrawal P.
American Journal of Medical Genetics 2023; 191(5): 1222-1226
This study found that tethered cord syndrome is relatively common in KBG syndrome, underscoring the need for early detection and intervention.
All
Publications
1 / Clinical Criteria for Filum Terminale Resection in Occult Tethered Cord Syndrome
Klinge PM., Leary OP., Allen PA., Svokos K., Sullivan P., Brinker T., Gokaslan ZL.
Journal of Neurosurgery: Spine 2024; 40(6): 758-766
This study establishes a 15-item clinical symptom scale in occult TCS cases (normal MRI) and shows that patients scoring >6 experienced symptom improvement in 89% at 3 months and 68% at 12 months after filum resection — supporting surgical selection based on clinical criteria.
2 / Diseased Filum Terminale as a Cause of Tethered Cord Syndrome in Ehlers‑Danlos Syndrome
Klinge PM., Srivastava V., McElroy A., Leary OP., Ahmed Z., Donahue JE., Brinker T., De Vloo P., Gokaslan ZL.
World Neurosurgery 2022; 162: e492-e502
This histopathological study reveals collagen and biomechanical abnormalities in the filum terminale of patients with Ehlers–Danlos Syndrome, indicating that even radiologically normal filum can tether; surgical release led to symptomatic improvement in these patients.
3 / The Surgical Histopathology of the Filum Terminale: Findings from a Large Series of Patients with Tethered Cord Syndrome
Abdulrazeq H., Leary OP., Tang OY., Karimi H., McElroy A., Gokaslan Z., Punsoni M., Donahue JE., Klinge PM.
Journal of Clinical Medicine 2024; 13(1):6
Examined filum terminale specimens from 288 TCS patients: 97.6% contained peripheral nerves, 70.8% had ependymal cells. Approximately 41% showed fatty infiltration and 7.6% dystrophic calcifications—supporting a rich histopathological spectrum underlying TCS.
4 / 171 Not Just a Matter of Retained Embryonic Spinal Cord: Histopathology of the Filum Terminale in Tethered Cord Syndrome
Abdulrazeq, H., Tang OY., Leary OP., Ayala C., Najib H., Gokaslan ZL., Donahue JE., Klinge PM.
Neurosurgery 2024; 70(Supplement_1):41-42
Among 288 surgeries, histology revealed peripheral nerves (97.6%), ependymal cells (70.8%), ganglion cells (38.5%), neuropil (15.3%), plus vascular/inflammatory changes—highlighting overlooked pathology due to mechanical stress on the filum.
5 / Adult-Onset Tethered Cord Syndrome: Case Series from a Comprehensive Interdisciplinary Spine Center
Leary OP., Hagan M., Sullivan P., McElroy A., Syed S., Liu DD., Donahue JE., Scarfo KA., Carayannopoulos AG., Li J., Svokos K., Fridley JS., Gokaslan ZL., Oyelese AA., Klinge PM.
Interdisciplinary Neurosurgery 2023; 33:101773
This study establishes a 15-item clinical symptom scale in occult TCS cases (normal MRI) and shows that patients scoring >6 experienced symptom improvement in 89% at 3 months and 68% at 12 months after filum resection — supporting surgical selection based on clinical criteria.